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Another type of GEMM for BRAF V600E -mutated gliomas is the replication-competent avian sarcoma-leukosis retrovirus and the corresponding avian leukosis virus A (RCAS-TVA) system, which allows for somatic gene delivery to cells that are engineered to express cell surface receptor TVA using a cell type-specific promoter such as Nestin, which is a common marker for neural stem cells (112, 113)

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