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Additionally, berberine enhanced apoptosis of colonic macrophages and decreased proinflammatory cytokine production in colonic macrophages and epithelial cells of DSS-treated mice

The lifespan and turnover of microglia in the human brain

Beyond efficacy: Ensuring safety in peptide therapeutics

Feed-forward regulation between cellular senescence and immunosuppression promotes the aging process and age-related diseases

While the tyrosine kinase activity of IGF-1R is needed for downstream AKT activation, MAPK activation takes place without it (60), requiring in this case the C-terminal region of the receptor (61)