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In metabolically demanding retinal cells, healthy mitochondria essential for sustaining cellular functions and preventing energy-depletion-induced cell death

The intracellular lactate dehydrogenase (LDH) activity of living cells is relatively constant during the culture, while impaired cells lead to LDH leakage to the culture medium ( 2 O 2 , either in the presence or absence of peptides, was determined by using the spectrophotometric method

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[ 1 ] Their work led to the characterization of DSIP, which was published in 1977 after more than a decade of research