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Heme binding to human alpha-1 proteinase inhibitor

Neotrop Ichthyol 7:103108 Anjum NA, Ahmad I, Mohmood I, Pacheco M, Duarte AC, Pereira E, Umar S, Ahmad A, Khan NA, Iqbal M, Prasad MNV (2012) Modulation of glutathione and its related enzymes in plants responses to toxic metals and metalloidsa review

This difference is probably attributed to the additive effect of the offensive drug on the accumulation of PGA and hence such agents should be discontinued