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However, technological advancements have shown that previously thought-to-be sterile tissues and organs, such as the lung, breast, liver, pancreas, prostate, and kidney, contain low-biomass microbial populations, paving the way for more study in related domains (Nejman et al., 2020, Wong-Rolle et al., 2021)

Free Radic Biol Med 25:287297 Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency