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This discrepancy may be explained not only by variations between cultured cells and living organisms but also by the time during which starvation is conducted in cell culture (12 h) and in animals (2448 h)

His work has led to advances in the understanding of how cells dispose of misfolded proteins that cause cellular dysfunction as well as the development of a pipeline of ATD drugs that could eliminate the need for liver transplantation in those with the disorder

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Furthermore, p38MAPK and JNK have been associated with AD-like lesions caused by diabetes mellitus (Kim and Song, 2020)