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PARP-1 (poly-ADP-ribose polymerase 1) is a DNA repair enzyme that consumes NAD + to synthesize poly-ADP-ribose chains at damage sites

doi: 10.1016/j.lfs.2022.121072

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Earlier this month, Reuters reported that Acting FDA Commissioner Kyle Diamantas met with representatives of rare disease groups in a bid to fix relationships after they soured under former FDA Commissioner Marty Makary when FDA declined to approve several rare disease treatments