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and (3) the contribution of local oxygen reservoirs, such as those in myelin sheaths (Morelli and Scholkmann, 2023

Cell 154 , 430441 (2013)

It was only with the availability of dioxygen did pathways evolve (Kreb Cycle, mitochondrial electron transport/oxidative phosphorylation) that allowed pyruvate to be fully oxidized to carbon dioxide, with the release of much more energy