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For 20% or greater weight loss, it was 38.5% versus 6.0%

doi: 10.1530/REP-18-0589 57 BarrachinaFBattistoneMACastilloJMallofrCJodarMBretonSet al

These findings underscore an intricate interplay among genetic mutations, TME heterogeneity, and resistance to ICIs in GBM

Its onset is usually acute and associated with increased output of urine, associated thirst, tiredness and weight loss (the four Ts of toilet, thirst, tiredness, and thinner)