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However, the reaction is reversible and the enzyme has a high K m value for oxalate (22 mM) 30

Biochem J 255 : 7983

Fourth, combination therapy: co-delivery systems (e.g., lipid-based vesicles co-encapsulating anti-inflammatory and urate-lowering agents) synergistically address inflammation and hyperuricemia, simplifying treatment regimens (Li et al., 2023)