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Other ingredients are used to maintain the stability of formulation

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In this study, we develop a new strategy to enhance OA therapy by using nanoparticles (NPs) to convert the senescent microenvironment of articular cartilage (with accelerated cartilage degradation) into a pro-chondrogenic environment that favors cartilage generation

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Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)