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Before system spread, the primary replication site of CVB is the mucosa found in the gastrointestinal or the upper respiratory tracts (131)

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However, after long-term exposure to stress environment and induced TP53-mediated apoptosis, the expression of TIGAR decreased, suggesting that the induced apoptosis might reflect the loss of protection of survival signal induced by TP53 (Bensaad et al., 2006)

Indirect manipulation of the dopaminergic system is also caused by the methionine-cholinefolate deficient diet (MCFD)

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