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Typically, the bacterium utilizes highly selective/unspecific porins (P66, P13, Oms28, BB0406) that open and close in response to specific stimuli and allow passive diffusion, or, active transport, which exploit the free energy from ATP hydrolysis to pump the solutes against concentration gradients [Citation256,Citation308,Citation309]

The following section provides a detailed review of the major chemical constituents and their pharmacological activities in Scrophulariae Radix