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Lebovitz HE, Fleming A, Cherrington AD, et al
Abbreviations A: -Amyloid AchE: Acetylcholinesterase E AD: Alzheimer disease APOE: Apolipoprotein E APP: Amyloid precursor protein BDNF: Brain-derived neurotrophic factor DMEM: Dulbeccos modified Eagles medium FBS: Fetal bovine serum FITC: Fluorescein isothiocyanate HBSS: Hanks Balanced Salt Solution H 2 DCFDA: 2,7-dichlorodihydrofluorescein diacetate JC-1: 5,5,6,6-tetrachloro-1,1,3,3-tetraethylbenzimi- dazolylcarbocyanine iodide MCI: Mild cognitive impairment MMP: Mitochondrial membrane potential MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide NGF: Nerve growth factor NMDA: N -methyl-D-aspartate PBS: Phosphate buffered saline PEPT1: Peptide transporter 1 PEPT2: Peptide transporter 2 ROS: Reactive oxygen species TrkA: Neurotrophic tyrosine kinase receptor type 1 References Thies W, Bleiler L: Alzheimers Association, 2011 Alzheimers disease facts and figures

Neither compound has completed dedicated cardiovascular outcomes trials (CVOTs), which are typically required post-approval
Testing has revealed that 12-58% of peptide products from various sources show contamination, incorrect sequences, or excessive endotoxin levels