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ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]

Pain relief after Gamma Knife is delayed and may take weeks or months, so it may not be ideal when rapid control is needed

The complexity of glutamine metabolism means that the development of a one-size fits all wonder drug against all glutamine-dependent tumours is unlikely

This distinction is the single most-confused point in this whole topic

42 Quantification of 8-oxo-dG in DNA was performed using mass spectrometry/liquid chromatography on a LCQ Advantage MAX system (Thermo Electron Corporation, Waltham, MA, USA) and expressed as pmol per mg DNA