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Increases in the accumulation of reactive oxygen species are related to polymorphisms in antioxidant enzymes such as glutathione peroxidases and glutathione S-transferases, which are linked to an increased risk of vascular disease

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Constipation Advise patients of the potential for severe constipation, including management instructions and when to seek medical attention (see ADVERSE REACTIONS and CLINICAL PHARMACOLOGY)

A naturally occurring coenzyme found in nearly every cell, NAD+ plays a key role in energy production and overall balance

Martensson J, Jain A, Meister A