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In addition, hematoxylin & eosin (H&E) staining indicated that there was no irritation or damage to the skin tissue after treatment with each group, confirming the safety of the developed system (Fig

But if you have a 500 g supplement and only want to take B12 once a week, you can add 5 of them together to equal 2,500 g and match our EFSA recommendation

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[16] [18] Animal studies have not demonstrated teratogenicity, but high doses in pregnancy may theoretically increase the risk of fetal oxalate nephropathy or other metabolic disturbances