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doi: 10.3201/eid2303.161552 248 WilkinsonT

Glutathione is found in nearly every cell in the body and plays a critical role in neutralizing free radicals and mitigating oxidative stress and inflammation

This indicates that the upregulation of glutathione synthesis within TLS is possibly reflected by increased urinary GSH concentrations

Furthermore, PDE5 inhibitors were shown to inhibit the oncogenic activity of -catenin either by repressing its transcription or promoting its proteosomal degradation in several colon cancer cells (134136)