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Transfusion-dependent -thalassemia patients may experience brain iron overload, potentially leading to cognitive impairment, in contrast to non-transfusion-dependent patients [43]

In the acute phase of AD, Th2-mediated immune reactions initiate the release of pro-inflammatory cytokines, further perpetuating the inflammatory cascade (45)

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Thus, as data about the SSZ-sensitivity of the cystine uptake were not presented for days 100 and 130, the lack of differential cystine uptake found in this study at the older ages might rather be a consequence of decreased EAAT activity