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Tirzepatide is a first-in-class dual incretin receptor agonist a single molecule that activates both the GIP (glucose-dependent insulinotropic polypeptide) and the GLP-1 (glucagon-like peptide-1) receptors, which is why it is often nicknamed a twincretin. [7] By engaging two incretin pathways it enhances glucose-dependent insulin secretion, promotes satiety, and delays gastric emptying, producing large effects on both glycemic control and bodyweight

At baseline, the mean chronological age with a standard deviation of 47.46 8.33 was comparable to the mean biological age of 47.07 7.21 years (mean difference = 0.39 years, 95% CI 1.80 to 1.03

doi: 10.1016/j.bbrc.2017.02.057 93

Fundamentals of Cancer Metabolism

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