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It exerts its effects through multiple mechanisms, including: VEGF receptor modulation (vascular endothelial growth factor)promoting angiogenesis and blood vessel formation Growth hormone receptor interaction facilitating tissue repair and regeneration Nitric oxide pathway activation improving blood flow and reducing oxidative stress FAK-paxillin pathway signaling crucial for cell migration and wound healing Modulation of inflammatory cytokines reducing excess inflammation while preserving healing responses These are cascading processes

Degnan PH, Barry NA, Mok KC, Taga ME, Goodman AL

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The efficacy of each analgesic administered should be determined and only one drug should be titrated at a time

10.1016/S2213-2600(13)70286-8 Lancet Respir Med