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Researchers studying NAD+ biology or methyl-donor pools should evaluate primary sources directly and note that NNMT inhibition has distinct mechanistic implications compared to direct NAD+ precursor supplementation with molecules like NMN or NAD+ itself

Their study revealed that hepatocyte glucose output decreased by 50% with NNMT knockdown, while NNMT overexpression increased it by 1.4-fold

Compared to aforementioned cross-sectional and casecontrol studies, we performed several large populations encompassing over approximately 10,000 NAFLD patients and over 780,000 controls, conducted state-of-art approaches of causal analysis (various MR methods) to minish reverse causality and unobserved confounding impact, and eventually, offered sufficient power to evaluate the causal effect of vitamin B12 concentrations on NAFLD risk

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