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However, most of the drugs mentioned in the article (such as andrographolide, rapamycin, azathioprine, JAK inhibitors, etc.) have shown potential in mechanistic studies, but their clinical translation faces three major obstacles: imprecise targeting, safety concerns, and difficulty in preventing drug resistance. Some drugs lack cell or tissue specificity, such as insufficient local drug concentration in the intestine, and are prone to systemic side effects

Ludvigsson J, Ludvigsson M, Sepa A

Other black cohosh constituents have been shown to act on serotonin and other neurotransmitter receptors, which could contribute to black cohoshs ability to relieve menopausal hot flashes, reduce anxiety, and improve cognition

Qiu YH, Xu YL, Zhang WH

Jonsson, P