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Tumor hypoxia unveiled: insights into microenvironment, detection tools and emerging therapies

The bone structure of the animals which received 400 mg/kg of EEMS appeared normal, with no destruction seen

Notably, Psa-AR exhibited a prolonged degradation effect, maintaining over 99% protein knockdown within the 96-h observation period, which was primarily promoted by the assembly induced retention effect produced by the in situ assembled nanostructures 50 (Fig