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A significant portion of ER glutathione is oxidized, with a [GSH]/[GSSG] ratio that can reach 3:1

Part Fibre Toxicol 21:116

Bioidentical Hormone Replacement Therapy (BHRT) is a method of restoring the balance of your hormones using compounded hormones that are biologically identical in structure to those that your body naturally produces

In the present investigation, MTX challenge induced ER stress and UPR mainly through the PERK/CHOP pathway, consistent with previous studies on MTX-induced hepatic injury (Schmidt et al., 2022), nephrotoxicity (Song et al., 2021), and cognitive impairment (Lv et al., 2020)

This dual behavior, referred to as the Estrogenic Paradox of resveratrol, reinforces its classification as a selective ER modulator [14]