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Via erastin-treated HT 1080 cells by RNA-Seq and RT-qPCR, the upregulation of the ER stress response gene cation transport regulator homolog 1 (CHAC1) was validated to be a significant pharmacodynamic marker of system xc- inhibition and a transcriptional PD marker for exposure to erastin and other agents that deplete cells of cystine or cysteine [83, 224, 225]

Therefore, pursuing research into the optimal planning of drug dosages post-combined anti-DTP and anticancer therapy holds significant promise

AdipoQ is a novel adipose-specific gene dysregulated in obesity

Rennie MJ, Hundal HS, Babij P, MacLennan P, Taylor PM, Watt PW, Jepson MM, Millward DJ

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