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4 For example, in the mitochondrial respiratory chain, the electron transfer process involves sequential redox reactions accompanied by the gradual release of energy

doi: 10.1016/j.jaci.2005.12.1331 24 PereiraAFMCavalcanteJSAngstmamDGAlmeidaCSoaresGSPuccaMBet al

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Once key junctional proteins are disrupted, gaps form between endothelial cells, resulting in the loss of BBB selective permeability and effectively opening the gateway for the uncontrolled leakage of macromolecules (146)