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Mehndiratta MM

Chronic mild stress leads to aberrant glucose energy metabolism in depressed Macaca fascicularis models

Single-cell RNA sequencing (scRNA-seq) was employed to investigate the expression and biological functions of biomarkers linked to metabolites

The unfolded protein response is an adaptive response that restores ER homeostasis by activating the three proximal sensors TF6 (activating transcription factor 6), PKR-like endoplasmic reticulum kinase, and inositol-requiring enzyme 1 (IRE1) under short and mild ER stress, but severe and prolonged ER stress activates downstream effectors, including JNK, CHOP (C/EBP homologous protein), and members of the cystathionine and Bcl2 families, leading to apoptosis [105,106]