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Its brightening effects are only permanent if you keep it up (by avoiding exposure to sunlight)

The Lancet 386(9996):896912

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Acknowledgements Illustrations were created with Abbreviations APOE Apolipoprotein E AD Alzheimers disease FAD Familial Alzheimers disease MCI Mild cognitive impairment APP Amyloid precursor protein PSEN1 Presenilin 1 PSEN2 Presenilin 2 A Amyloid beta NFT Neurofibrillary tangles ABC ATP-binding cassette ABCA1 ATP-binding cassette transporter 1 ABCG1 ATP-binding cassette subfamily G member 1 LDLR Low-density lipoprotein receptor VLDLR Very low-density lipoprotein receptor LRP1 Low-density lipoprotein receptor-related protein 1 APOER2 Apolipoprotein E receptor 2 HSPGs Heparan sulfate proteoglycans TREM2 Triggering receptor expressed on myeloid cells 2 CNS Central nervous system BBB Blood-brain-barrier iPSC Induced pluripotent stem cell DAM Disease associated microglia AAV Adeno-associated virus Author contributions AAB reviewed the literature, wrote the manuscript and prepared the figures

AMPK phosphorylates NRF2 at the Ser550 residue located in the canonical NES sequence, facilitating NRF2 nuclear accumulation, probably by inhibiting nuclear export [212], and this effect is enhanced by GSK-3 inhibition [213]