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Hui J, Tang NL, Li CK, et al

A prospective study involving IBD patients with aberrant metabolic profiles recorded an increase in HPRT activity following the thiopurine-allopurinol therapy but no effect on TPMT activity, suggesting that allopurinol may affect HPRT through an unknown mechanism (Seinen et al., 2013)

In conclusion, the cascade clusterzyme described in this study offers a method for future clinical implementation that is both safe and effective in treating oral biofilm-induced periodontitis [38] (Table 4)