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Interestingly, bortezomib, a potent proteasome inhibitor known to increase microtubule polymerization in neuronal cell line (Poruchynsky et al., 2008), also induced excessive microtubule polymerization in the cell bodies of DRG neurons by increasing hyper-stable delta 2 tubulin (D2) (Pero et al., 2021)

This improves insulin sensitivity and regulates key metabolic pathways, essentially mimicking the positive metabolic effects of exercise

Influence of the brain-gut axis on neuroinflammation in cerebral ischemia-reperfusion injury

Cell Factories 20:25

rather it reduces mitogenic activity of insulin by an AMPK-dependent mechanism