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Biomarkers of major depressive disorder: knowing is half the battle

2025 Jan 27;17(1):e78045

R., Spielmann, G., & Irving, B

Recent Advances in Cocoa Flavanols on Nrf2 Pathway/Antioxidant Defenses and Inflammatory Process Although polyphenols exert their antioxidant capacity mainly through the direct neutralization of free radicals and chelating metals, such as Fe2+ and Cu+ [119,120], there are other mechanisms that have been reported, such as the stimulation of mitochondrial biogenesis through the activation of the SIRT1 and Nrf2 signaling pathways [120,121]

When active glutathione, also known as GSH, falls below 90%, free radicals begin to cause damage