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As presented in Figure 1 , islet-graft-confronted immune responses can be divided mainly into three types, including (1) autoimmune recurrence and alloimmunity, (2) instant blood-mediated inflammatory reaction (IBMIR), and (3) hypoxia and oxidative stress

Roles in cancer stem cell control ROS such as superoxide (O2), hydrogen peroxide (H2O2), and hydroxyl radical (OH.), are highly chemically reactive species derived from molecular oxygen (68,69)