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These beneficial effects may be due to the formation of detour circuitswhich encompass spared tissue surrounding the lesionand could reconnect locomotor circuits [69], thus enabling afferent inputs to be processed and conveyed to the cortex [73] and improving spinal reflexes, even below the injury [74]

The intrinsic tryptophan fluorescence of BSA is sensitive to binding of any ligands at these two binding sites and has been used as a convenient probe to assess the albumin-binding affinity of several drugs and xenobiotics [52,53,54,55,56]