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Description

Human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice

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Although our data align with the notion that inhibiting NMDA receptor signalling in the hypothalamus decreases food intake and body weight 8,40 , earlier studies have demonstrated that NMDA receptor antagonism in the brainstem attenuates vagus-mediated meal-related satiety 6,7,42

Funding This study was supported by grants from the National Natural Science Foundation of China (82071973, 81471729), 2020 Natural Science Foundation of Guangdong Province (2020A1515011022), 2023 Natural Science Foundation of Guangdong Province and Key Research Platform and Project of Guangdong University (2022ZDZX2020)