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The annulus fibrosus forms the outer ring, a complex series of fibrous layers made primarily of type I collagen arranged in alternating diagonal patterns

Among these, proteoglycans adsorb large amounts of water through glycosaminoglycan side chains and form aggrecan complexes by binding with hyaluronic acid, creating a high osmotic pressure environment that maintains the highly hydrated state of the NP

2008 Feb 8;283(6):35743583

Bacteriostatic Water Storage: The Temperature Threshold That Changes Everything Here's what the FDA-registered 503B facilities don't emphasize enough: the question of whether BAC water needs refrigeration has two completely different answers depending on one variable