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Additionally, ROS-mediated activation of p53 represses SLC7A11 transcription impairing cystine uptake via system Xc - and further diminishing GPX4 activity [17, 18] Mitochondria significantly contribute to ferroptosis via oxidative metabolism

Acknowledgements Special thanks to Assoc

The distinct associations observed between TSPO levels and sleep duration in frontostriatal versus limbic systems suggest that TSPO levels in different neural systems may be differentially related to sleep duration

Toxicol In Vitro 17:675680 Gomez-Lechon MJ, Ponsoda X, OConnor E, Donato T, Castell JV, Jover R (2003b) Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS