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The first clinical trial involving AuNPs began in 2005, led by CytImmune Sciences, testing Aurimune (CYT-6091), which used AuNPs conjugated with TNF- to target tumors via the EPR effect, reducing systemic toxicity

Plasma exposure increases with chain length up to PEG8, where it plateaus near the levels of the naked antibody

Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjogrens syndrome mice