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This ternary complex slows even higher clearance, such that in adult humans, the total IGF-1 concentration in the circulation is around 100 nM

Considering the fact that intracellular accumulation of surplus copper exceeding the threshold would lead to cuproptosis, a process associated with ROS production and oxidative stress, this work pays attention to the crosstalk between cuproptosis with oxidative stress-associated regulated cell death mechanisms in order to provide new targets and new ideas for targeted cancer therapy (Fig

These amalgamations have the potential to augment treatment effectiveness while mitigating unintended toxicities