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3.1 Mitochondrial respiration Although the metabolic scenario of NF1 mutant cells is poorly defined, some bioenergetic alterations are starting to surface

A broad panel of antibodies was employed, including those for FOXO4, p53, phospho-p53, p21, p16, cleaved-Caspase3, BAX, BCL-2, testosterone synthesis enzymes (3-HSD, CYP11A1, CYP17A1), and various SASP factors (IL-1, IL-6, TNF-, TGF-)

For example, the protein may interact with certain protein partners with the switch in one redox state, and with other protein partners when the switch is in the alternate redox state

TGF-1 activates Smad2/3, PI3K/Akt, ERK1/2, GSK-3 and/or p38MAPK signalling to induce pulmonary fibrosis and EMT

When skin flares up, it's rarely just one thing going wrong