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Consistent with this, Lpez-Benito and colleagues [100] demonstrated that the knockdown of ARMS in the cortex and hippocampus resulted in increased BDNF secretion

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Classical GPCR signaling is initiated by an extracellular ligand binding, which induces a conformational change in the receptor that initiates binding and activation of intracellular heterotrimeric G proteins (G i , G q , G s ) (Weis and Kobilka, 2018)

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