eNeuro 10: 406-423
Spatial hubs for crosstalk: contacts and microdomains Organelle contact sites are active hubs where multiple reactive chemistries are choreographed rather than isolated: at mitochondriaER contacts (MAMs), tightly coupled Ca and lipid transfer is synchronized with ROS generation and detoxification, so that ONOO , H 2 O 2 and RSS can be relayed across adjacent membranes via redox relays and peroxiporins, shaping metabolism, unfolded-protein responses and cell-death thresholds, at mitochondrialysosome and peroxisomemitochondria interfaces, fatty-acid flux, the labile iron pool (LIP) and ROS/RSS hand-offs are co-regulatedperoxisomal -oxidation and catalase buffering, lysosomal iron mobilization and mitochondrial electron transport together set the likelihood of Fenton chemistry and lipid peroxidation (DiGiovanni et al
Arsenic effects extracellular matrix through upregulation of MMPs resulting in degradation of extracellular matrix having consequences in cellular migration, angiogenesis, proliferation and apoptosis
Kolfenbach JR, Deane KD, Derber LA, ODonnell CI, Gilliland WR, Edison JD, et al
This is beneficial for resistance to reinfection by the same or different pathogens, including parasites (110)
