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Metformin induces cell cycle Arrest, reduced Proliferation, wound healing impairment in vivo and is associated to clinical outcomes in diabetic foot ulcer patients

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doi: 10.1186/s10194-021-01271-1 204

Our mechanistic findings can provide a rational approach for developing cancer treatments through targeting the ASXL1-BRD4 interaction with small molecule inhibitors, because the cancer-specific truncation variants of ASXL1 but not full-length ASXL1 have previously been shown to appreciably interact with BRD4 and induce myeloid malignancies in animal models 6,26,39

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