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J Clin Periodontol 36:850856

This is because they generally act on more lipid-soluble (nonpolar) substrates, and their purpose is to make the compounds MORE POLAR and therefore, MORE EASILY EXCRETABLE by the kidney and biliary tract

This depletes the active form of vitamin K needed to carboxylate clotting factors II, VII, IX, and X, thereby reducing their activity and prolonging clotting time as measured by the INR

However, in males, the adjusted odds of gout were not significantly different between current smokers and never smokers (AOR=1.00

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