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Cognitive impairment found in type 2 diabetes can progress to Alzheimer's disease by inducing vascular dysfunction and oxidative stress

However, some of the studies used injected SAMe, which may not have the same effects as SAMe taken as a dietary supplement

doi:10.1177/1535370213477988 Maddocks ODK, Labuschagne CF, Adams PD, Vousden KH (2016) Serine metabolism supports the methionine cycle and DNA/RNA methylation through de novo ATP synthesis in cancer cells