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Nature 607 , 585592 (2022)

10.1016/j.pneurobio.2011.06.003 Prog

Total body depletion of iron (absolute or true iron deficiency) will eventually result in a microcytic hypochromic anemia and hypochromasia (decreased rim of hemoglobin resulting in increased central pallor) will be evident in red blood cells on blood smear examination (see image on the right and images below)