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Specific Populations Age, Gender, and Body Weight Based on a population pharmacokinetic analysis in 183 patients with cancer (50 male and 133 female patients, age range from 22 to 89 years, and body weight range from 37.9 to 123 kg), gender had no effect on the exposure of palbociclib, and age and body weight had no clinically important effect on the exposure of palbociclib

According to routine clinical practice, which was the same as the prescribing information [13], patients received 500 mg/m 2 pemetrexed intravenously on day 1 of each 21-day cycle, with or without other antineoplastic agents [14]