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Elevated levels of O 2 , H 2 O 2 , OH , nitric oxide (NO), and glutathione disulfide (GSSG), peroxides, depletion of GSH, and oxidation of methionine and cysteine moieties in cataractous lenses, all indicate the involvement of ROS and RNS in cataract formation [5965]

JCI Insight 1:e89073

doi: 10.18632/aging.203131 129 TangLXiaoQMeiYHeSZhangZWangRet al

18 Continued efficacy was confirmed in a similar study in which Psoriasis Area and Severity Index (PASI) score improvements of at least 50%, 75%, and 90% was shown to be achieved by increasing percentages of participants over a period of years