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The reagent that is intended to use in the cell can use the technology of well known to a person skilled in the art to use.For example, can this type of reagent be encapsulated in the liposome, be described below subsequently and use.Liposome is the spherical lipid bilayer with aqueous interior.Can all molecules that when liposome forms, are present in the aqueous solution be mixed aqueous interior.The liposome content be protected from outside microenvironment destruction and, because liposome and cell membrane merge, thereby said content is sent the Cytoplasm that gets into cell effectively.In addition, because their hydrophobicity is directly sent little organic molecule in the cell

DeBose-Boyd RA

10.1002/ptr.5025 164 SarawiW

Annu Rev Immunol (2020) 38:70525

Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial