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PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA

Second, we acknowledge the observational nature of our experimental approach that, at the moment, precludes answering some salient mechanistic questions, such as factors leading to the decline of the systemic levels of dopamine, glutamate, and BDNF

10.1016/j.neulet.2018.06.016 126

M., Diniz, J

Consequently, it is imperative to conduct thorough analyses of the underlying mechanisms responsible for this resistance and to identify effective strategies aimed at delaying or overcoming drug resistance, ultimately improving the prognosis for HCC patients